In the year 1863, a time fraught with violent social upheaval, samurai of all walks of life flock to Kyoto in the hope of joining the Mibu-Roshi--a band of warriors united around their undying loyalty to the Shogunate system. In time, this group would become one of the greatest (and most famous) movements in Japanese history... the Shinsengumi!

In 2003 Kaze Hikaru won the Shogakukan Manga Award for shoujo.

From Viz:

Orphaned on the mean streets of Treasure Town, lost boys Black and White must mug, steal and fight to survive. Around them moves a world of corruption and loneliness, small-time crooks and neurotic police officers, and a band of sadistic yakuza who have plans for their once-fair city. Can they rise above their environment?

Won the Best U.S. Edition of International Material - Japan for the Eisner Award in 2008.

A twisted old man, gifted with extrasensory powers, silently holds sway over an entire block of apartments. The occupants are puppets for him to control. Life is his to give...and to take. But suddenly there is a new voice in his head, and before he knows it, a young girl with her own battery of psychic abilities has arrived to challenge him! Soon, the sprawling complex becomes a battleground between two minds possessing incredible, unimaginable power.
Note: Won the 15th Seiun Award for Best Comic (1984).

Monster weaves the riveting story of brilliant Dr. Kenzo Tenma, a famous surgeon with a promising career at a leading hospital. Tenma risks his reputation and promising career to save the life of a critically wounded young boy. Unbeknownst to him, this child is destined for a terrible fate.

A string of strange and mysterious murders begin to occur soon afterward, ones that professionally benefit Dr. Tenma, and he emerges as the primary suspect. Conspiracies, serial murders, and a scathing depiction of the underbelly of hospital politics are all masterfully woven together in this compelling manga thriller.

Note: Won the 46th Shogakukan Manga Award in the general category.

The continuation of Miiko Desu!
This time, Miiko is in the fifth grade, and the stories have become more exciting!

This series received the 1996 Shogakukan Manga Award for children's manga.

Touch is a shounen story about two twin brothers, a pretty girl next door, and that good old pastime of baseball.

Won the 28th Shogakukan Manga Award in the Shounen category.

From MangaHelpers:
The world is in a war against an alien race called "Mimics," who have taken over most of the world with a mission to eliminate the human race. Keiji Kiriya is a new recruit in the United Defense Force, which is battling against these "Mimics." On his first day of deployment, Keiji and his unit encounter "Mimics" and are all killed... Or was it all a dream? For some inexplicable reason, after every time he dies, he is resurrected and returned back to the day before the battle. Why does this happen to Keiji and how can he escape from this never ending cycle?

Note: Nominated for the Eisner award for the "Best U.S. Edition of International Material - Asia" in 2015.

Seito Shokun follows the life of Kitashiro Naoko, nicknamed Nakki, as she plows through life with her friends and family. Faced with hardships and struggle, happiness, sadness, love and tragedy... Nakki paces forth! A manga classic!

Won the 2nd Kodansha Manga Award for Shoujo in 1978.

From ryColaa:

Meet Jerry and Lok. They are two young guys in their twenties, working in the competitive world of advertising in Hong Kong. Their "sport" of choice is chasing girls, keeping a score for each, constantly searching for that elusive 100%.

Follow their journey filled with blood, sweat, tears, and laughter--even a mini marathon. The search for perfection has never been more fun!

Note: Won the Second International Manga Award in 2008.

From Tokyopop:
Ayumu Shiiba is studying for the all-important high school entrance exams. She is struggling to get by, but thankfully has help from her best friend Shii-chan, who is at the top of their class. Test results come back and their friendship falls apart when Ayumu surpasses Shii-chan’s scores and gets into her high school of choice while Shii-chan doesn’t! Losing Shii-chan is so painful for Ayumu that she starts cutting her wrists for comfort. Hoping for a fresh start, Ayumu arrives at her new high school and finally opens up to a new friend, Manami. But will Manami prove to be the friend that Ayumu truly needs or send her further in a downward spiral?

Note: Won the Kodansha Manga Award for shoujo in 2006.

Humanity, having faced extinction at the end of the 20th century, would not have entered the new millennium if it weren't for them. In 1969, during their youth, they created a symbol. In 1997, as the coming disaster slowly starts to unfold, that symbol returns. This is the story of a group of boys who try to save the world.

Won the Kodansha Manga Award in the category "Best General Manga" in 2001.
Won the Seiun Award for Best Comic in 2008.

A graveyard in contemporary Israel has an unlikely visitor. The elderly gentleman from Japan, a former news correspondent, lays a bouquet of flowers at the tomb of one Adolf Kamil. For he remembers the tale of three Adolfs: Kamil, a Jew who grew up in Kobe, Japan, the son of a baker; Kaufmann, only child of a German consul stationed at that port city and his Japanese wife; and the Fuhrer with whom the Far Eastern nation made common cause.

Won the 10th Kodansha Manga Award for general manga in 1986 (shared with What's Michael?).

Description from Viz: The story A, A' raises a troubling question: How would you feel if your lover died - and was replaced by a clone? Could you recreate your relationship with someone who was physically exactly the same but didn't share any memories of your life together? In 4/4, teenaged Mori flunks out of an ESP training program. But when he meets Trill, a beautiful Unicorn, his latent abilities begin to blossom... In X+Y, Hagio uses science fiction to explore questions of gender and sexual identity. Time has passed, and once again, Mori finds himself inexorably attracted to a member of the unicorn race - but this unicorn is male... and so is Mori. X+Y won Seiun Award in manga category in 1985

Akira is set in the post-apocalypse Neo-Tokyo of 2030, a vast metropolis built on the ashes of a Tokyo annihilated by an apocalyptic blast of unknown power that triggered World War III. The lives of two streetwise teenage friends, Tetsuo and Kaneda, change forever when dormant paranormal abilities begin to waken in Tetsuo, who becomes a target for a shadowy government operation, a group who will stop at nothing to prevent another catastrophe like that which leveled Tokyo. And at the core of their motivation is a raw, all-consuming fear. A fear of someone or something, of unthinkably monstrous power known only as "Akira".

Note: Won the 1984 Kodansha Manga Award for best general manga, won the Harvey Award for Best American Edition of Foreign Material in 1993 and was nominated for the Harvey for Best Graphic Album of Previously Published Work in 2002.

From Eternal Bunny Love:

Ami moves into a new house and finds a mysterious trapdoor in her room. From that trapdoor, pops out 3 strange animals. Iyo (rabbit), Issa (panda), and Kenta (bear) are from Animal Yokocho, which is where the trapdoor leads. Don’t underestimate these cute little animals, because they can cause a whole lot of trouble.

The manga won the award for children's manga at the 51st Shogakukan Manga Awards.

Shogo Ban, a college student from Fukuoka, likes to cook. Thanks to the owner of the restaurant where he works part-time, he finds himself working at the line of Roppongi's best Italian restaurant, Trattoria Baccanale, and discovers that the real deal isn't quite as easy as he'd thought. The manga follows Ban as he struggles to keep up with the hectic workload and his co-workers, along with issues outside the kitchen like his relationship with his girlfriend Eri, who he left behind in Fukuoka.

Bambino! received the 2008 Shogakukan Manga Award for seinen/general manga along with Takeshi Natsuhara's and Kuromaru's Kurosagi.

"Basara - The spirit of freedom which denies old authority, transcending traditions and customs."

Born under a prophecy that will liberate and unite Japan, Sarasa has had to take her brother Tatara's place as the "Boy of Destiny." Fighting for the oppressed, Sarasa journeys across Japan to gain allies and defeat her enemies--all while keeping her identity a secret!

Basara won the Shogakukan Manga Award for shoujo in 1992.

2300 years ago in China there existed a clan called the men of Bokk trained to aid and defend threatened cities with their lives. Kakuri, one of these men, is summoned to the little city of Ryo. Distrusted and even hated, Kakuri eventually gains the trust of Ryo's citizens as Tcho empire's vast army sets their camp on the other side of the river.

Bokko won the Shogakukan Manga Award in 1995.

From ShoujoMagic:

Yori's attitude has changed. He and his twin sister, Iku, used to be inseparable as children, but lately Yori's been different -- eager to be apart from Iku. Iku worries that he hates her, but the truth is far more scandalous. Now, Yori would risk losing everything to have his little sister. Iku loves her big brother enough that she would never risk losing him, and so she'll do what it takes to keep them together... but Yori doesn't want to have her that way -- as a sister dedicated to her twin. Can Iku ever love Yori not as a brother but as a man?

Boku wa Imouto ni Koiwosuru received the Shogakukan Manga Award for shoujo manga in 2008.