A story about two kids who go to Tokyo after their mother died and their stepfather kicked them out of the house. In Tokyo they meet up with a fellow orphan named Shigeru Ito. Thus begins their cynical tale of laughter and depression.

Very cute yaoi comedy about a country boy who goes to Tokyo to find his real mother. He's followed there by his best friend who's in love with him.

From: Easy Going Scans:

Fate brings two people who live in the same condo together on a typical afternoon. Ozawa (26) has just broken up with her boyfriend of five years and was in the process of trying to rebuild her life when she meets Oyamada who lives a couple floors below her. He is somewhat of a loner although he does have a few friends and his room is cluttered with all the random stuff that his impulse shopper brother sends him. Ozawa takes an interest with all the things in his room and the two start a friendship that slowly turns into something more.

From amber love pj scanlations:

It's about two best friends, Tamio and Takashi. The development of a friendship to something more as they grow up.

Living his life in rural Japan, Tamio is immediately intrigued by Takashi, the blond haired city boy who transfers into his elementary school. But Takashi is actually half Japanese, and despite his appearance he doesn't even know English and loves eating Japanese food even Tamio can't abide.

Tamio and Takashi become friends, and despite his perplexity with Takashi's foreign appearance, Tamio quickly develops a strong attachment to the other boy. Tamio earnestly hopes that he and Takashi can stay friends forever. But Takashi remains dissatisfied with life out in the boonies, insisting that someday he's going to leave all this behind.

Yet Tamio continues to hope and to do anything he can to ensure that Takashi will stay with him--or take him along--no matter where he goes in life, with an intense, endearing, wistful sincerity perhaps telling of sentiments more complicated than Tamio might think.

1. Iku and Keita are childhood buddies. Naturally, having been friends for as long as they can remember, when one started to play baseball, so did the other. During their final year in middle school, Keita's baseball career abruptly ended as a result of the severe injuries he sustained when saving Iku from being hit by a truck. Presently, they go to the same high school. But ever since that accident, Iku has distanced himself from both the game and his friend, presumably out of guilt. What does Keita think about this? It also contains a couple of other short stories such as Utsukushii Asu and Sakura No Junrei. 2. The Sakura Pilgrimage Sugaya believes that guys like Fujishiro, a highly accomplished student rumored to be the next student council president, live in a completely different world and have no impact on his life. That changes one fateful day when he catches Fujishiro making out with a teacher after school. Fujishiro pays Sugaya for his silence, but not without a parting jab at how easily Sugaya's confidence was bought. This appears to be a collection of one-shots. Also contain Bokura no Ashita no Houteishiki (Extra - 6) Sequel to Iku and Keita's Story

From Dangerous Pleasure:

Takahiko can't stand Aizawa, a student in another class. As for the reason why, it seems that Aizawa has his eye on Takehiro, a mutual friend.

To save Takehiro from Aizawa's evil clutches, Takahiko plans an onsen trip so he can reveal Aizawa's true colors. However, when he hears about this idiotic plan, Takahiko's best friend Magi is nice enough to play along, but...

Of course there's no way it could all go according to plan. The result is something Takahiko never anticipated!

For the students at the same school, flowers of love bloom in total chaos!

1-2) I Want to be Myself and I Want to Know More About You
Ookawa Taketo is in love with his Biology sensei, Tsuruoka. After he confessed, Sensei refused to accept him because he was dumped once by a student before. Will Ookawa’s determination and his strong love convince Sensei?

3) Route 17
Runner Tsuji is confessed to by his kouhai, star athlete Teranishi, but without waiting for an answer, Teranishi tells him to forget about it and runs off!

4) Hope This Can Be Forever
Hiromi's cool exterior hides his growing feelings for Yutaka, but suppressing his emotions where his childish kouhai is concerned is getting more and more difficult. The day is coming when Hiromi won't be able to hold back anymore...

5) The Feeling of Love
Seiji always though a charming smile would get him out of trouble, so he grins idiotically all time. But classmate Inoue only wants to see Seiji smile for real.

6) The Four Seasons at the Toda Flower Shop
Florist Shougo has been alone since his wife Kana died five years ago. Well, almost alone, her annoying and cheerful nephew Takao is determined to stay close to Shougo, no matter what! Takao's love is definitely more than uncle/nephew, but what about Shougo's feelings?

7) Mint Candy
Miyahara's wedding is a reunion for former college classmates stoic Kuze and light-hearted Takeda. Even knowing how cool Kuze is, Takeda is still surprised at his nonchalance, since Takeda always thought that Kuze had a crush on Miyahara...

From Operation Boredom:

Jin is a rock artist in the making, and in a relationship with Tama, a wanna-be bread maker. However, as Jin's popularity grows, he feels he doesn't have enough time for Tama, and breaks up with her. Tama agrees to call it off... A little too easily. The two go off their seperate ways and decide to meet new people, but is their relationship really truly over? Watch their piping hot love slowly unfold!

Inui Takeshi is the owner of a restaurant in trouble! He and his cute younger brother Yasutomo are trying to make a living, but business is just too slow. When regular customer and ex-host Ookami Kyousuke suggests an all-male version of a maid cafe, the brothers reluctantly agree to the idea. Ookami and fellow host Sannoumaru Miyabi move in with the Inui's and begin the adventures of Cafe Relish!

Short, cute 4-koma about an ageing cat's digestive problems.

The grandson of a commissioner absconds and forces a police officer to take him in.

He is blind. He lost his sight in his 20s while working as a manhwa artist.

She is deaf. She could not hear anything ever since young.

This is the story of how they met each other, how they seemingly get along with each other with virtually no verbal communication, and how they eventually fell in love.

Soo Ah discovers the cafe of dreams, young teahouse while floundering about trying to find a job.... Drinks sweet coffee while listening to baristas tell her of future dreams and hope.

"Irasshai!" Welcome to the most unruly cafe in Kichijouji and its charming staff of five who have absolutely nothing in common. When tempers rise, so do mop handles, giant boulders and repair bills. Meet Jun, a mild mannered high school student with a sharp tongue and superhuman strength. Tarou, a clean freak with a deadly aim in the art of mopping. Maki, a sloppy, lazy woman chaser. Minagawa, a talented pastry chef equally skilled in the arts of voodoo, and the impulsive, cheerful, though desperately unfortunate Tokumi. A feast of comedy based on the popular Japanese radio drama.

Chris Watanabe is a high-school teacher. When his father remarries, he finds himself with an English step-brother named Wataru. Wataru transfers to Chris' school, and just as the four of them are starting their new life together, their parents die in a plane crash. Now Chris and Wataru are living alone together. The elder is cute and the younger cool; what will their new life hold for them!?

Two brothers, Shunpei and Kyouhei, have very opposite characters but share a crush on their cute sister Anko. The three of them live with their excentric father, may (or may not) have diffferent mothers, have fun, lots of tantrums and try to lead a happy life in junior high school.

From Omanga:

Eiji Otsuka and Sho-u Tajima at it again, Eiji in a much more minor role this time, however. In any case, this a relatively older and short comedy series (4 volumes) that should be a fun break from their usual mayhem with MPD (Multiple Personality/Dissociative Identity Disorder) .

In 1994, this manga was published as a whole under title "BROTHERS High School".

Kondo Masahito is a tough high school senior, while his older brother Yoshio is a calm and gentle kindergarten teacher, so it is not rare that younger brother protects the older one. Different personalities make it difficult for Masahito to understand his brother, but he still tries.

Chapters 5-9 are oneshots:
5) Ghost --Setagaya-ku no Maboroshi--
6) Amai Natsu no Kyousoukyoku
7) Unbalanced・Tart
8) Kimi wa Nemuru
9) DEAR / Ganbare! Kagaku-bu

The story of Ciguatera follows Ogino, who is bullied in high school along with his friend Takai. The two rely on their passion towards motorcycles and desire to get one to add some hope and vigor to their otherwise bleak lives. The two are learning to drive in secret at a driving school, and it is there that Ogino's life begins to change forever. The manga follows a variety of characters through their high school and working lives, through their struggles, their triumphs, their dreams, their futures, their love, life and loss.

As a child, Kawagoe Haruma eagerly awaited the birth of his little sister. However, his mother had a miscarriage, followed by an operation that left her barren. That Christmas, Haruma made his Christmas wish. It was a wish so innocent and heartfelt that it was accepted instantly, unbeknownst to him.

Many years later, on Christmas morning, college student Haruma is awoken by a woman riding a hovering motorcycle and claiming to be Santa Claus. She throws him a bag, and he opens it to find his new little sister!

Complaining to Santa Claus that he made this wish a long time ago, she tells him that it takes much longer for a sister than it does a toy car. After naming her Choko because of the Anchoko (mini-guidebook) she carries around, they begin their new life as brother and sister in a crazy apartment building filled with interesting neighbors.

1-2) Chikan Diary
Yuuto is a first year student at an exclusive private school for boys where everyone is a virgin except for the new transfer student Hachiouji. As part of the student news paper it's Yuuto's job to get all the dirty details or else spend the rest of his life as a virgin!

3) Journey of Lost Love
When his lover gets married heartbroken Atsushi decides to take a tropical vacation to relieve his stress. Nothing seems to be working until pushy tour guide Rubi decides to help Atsushi out. But the only thing Rubi seems interested in seeing is Atsushi's body!

4) The Perverted Daddy Long-Legs
Orphan Mizuki is suddenly pulled off his paper route and offered a high paying job taking care of a sick company President. Mizuki's new duties for entertaining the bed-ridden, surprisingly handsome young man aren't quite what he anticipated...

5) An Awkward Kiss
Morihira has issues moving on to the next level of intimacy with his lover Ueda because of a complex with his face, but Ueda mistakes it as Morihira not liking him. Will this pair ever move to the next level?!

6) I Won't Even Lose to Sailor Suits
Shintarou's teacher/boyfriend went to work at an all girls school and suddenly told Shintarou not to see him anymore. What is poor Shintarou to do?! Putting on a girl's uniform seems like a good start.