Twenty-nine-year old Kurose Kazumi is a programmer in an eroge company and has played plenty of galges when he was younger, but he's completely uninterested in young girls. A chance encounter changes that when a confused middle schooler approaches him due to a misunderstanding, but he realizes how sweet she is and wants to keep meeting her.

Three sisters, Isuzu, Aoba, and Haruna, inherit an electronics store in Akihabara from their dead father, but their business is not doing well. Creditors have threatened to seize their shop if they cannot pay their bills. They find a heart-broken otaku named Takezou Muto on the doorstep of their shop, and he is able to save the day and the shop with his quick thinking. He is hired on permanently, and Haruna, the motherly sister, asks him to transform their store into a money-making enterprise. Takezou dreams of it becoming an otaku paradise, much to the delight of Isuzu and much to the consternation of Aoba.

Rikitaro is a musician whose dream is to become a rock star just like Jimi Hendrix or Jim Morrison, but at the age of 27 that dream is fading away rapidly.
Ooishi is a 3 time world boxing champion who recently retired and is now in the entertainment world, shooting a boxing reality show.
These two unlikeliest of people cross paths one day, but both of them think nothing of it until weeks later. Rikitaro is given one last shot by a record label to sign a deal but before that, they need him to get into better shape so that he is easier to sell. He stumbles upon a boxing gym which also happens to be the same gym Ooishi is filming his show.
As fate’s wheels start to turn, neither man realizes that they will work together to train the best boxer ever, even better than Ooishi himself.

A childhood dream has led Ha Min to work as a conductor for Pidgeon-ho, a slow-train in a backwater country. But the life of the slow-train is unexpectedly ending and Ha Min must transfer to another train in the city. People in the new railroad are different and he soon realizes that there are some things in the slow-train to be missed. On a closer look though, Ha Min discovers that not all is bad, and maybe his dream is nearer than he thinks...

Atsushi Ando (15) moves back to his home town with his family after 6 years. The story focuses on the fortunes and misfortunes he encounters in this town mostly due to pranks pulled by the ghost of his older brother, Hitsushi Ando, AKA Q-Chan, whose death prompted the family to move away in the first place. The catch is, only Atsushi can see his brother's ghost.

Takaki loves ranking the popular and beautiful girls at his school. The one standing at the top is the foreign transfer student Emilia Shutrause, and being a student from Europe, she is extremely popular among the male students at Takaki’s high school. Although he was just a spectator of this school idol, that would change when one day he accidentally bumps into Emily (Emilia’s nickname) and he finds out her secret...

Haunted by a space flight accident that claimed the life of his beloved wife, Yuri finds himself six years later as part of a team of debris cleaners on a vessel called the Toy Box charged with clearing space junk from space flight paths. The team consists of Hachimaki, a hot shot debris-man with a sailor's affinity for the orbital ocean; Fee, a chain-smoking tomboy beauty with an abrasive edge; and Pops, a veteran orbital mechanic whose avuncular presence soothes the stress of the job.

Note: Won the Seiun Award in 2002.

An older brother discovered his interest in cross-dressing and totally grossed out his sister. After consulting online message board, he decided he will play the role of older sister instead to build better relationship with her.

A spin-off story focuses Kazuma Ikezawa (King Kazuma), Natsuki Shinohara's cousin, as he battles his way in the Oz Martial Art Competition.

NEETs are people who have chosen not to be part of society due to personal problems or just straight-out laziness.

This story is centered around a certain young woman who has become a NEET right after high school without even realizing it. In her case, though, it's not that she doesn't want work - but rather that there is not a single job out there which can fulfill her very specific criteria...

Oh, well...at least her mother understands her!

The heroine of the story, Amu Hinamori, is a student at Seiyo Elementary. At first glance, her classmates refer to her as "cool and spicy" and rumors speculate about her personal life. However, her real personality is that of a very shy girl who has trouble showing her true personality. One night, Amu wishes for the courage to show her "would-be" self, and the next morning finds three brightly colored eggs—red, blue, and green—in her bed. At first, she is alarmed, but realizes she must have really wished to change. These eggs hatch into three Guardian Characters: Ran, Miki, and Su. The Guardian Characters aid Amu in discovering who she truly is and help fulfill Amu's dreams. Amu's life becomes much more complex as she struggles to deal with her "would-be" selves and the Seiyo Elementary's Guardians, who recruit Amu as the Joker to search for X Eggs and X Characters, the corrupted forms of peoples' dreams. Meanwhile, the Easter Company is extracting people's eggs in search of a special egg called the Embryo. The Embryo is believed to grant any wish to the one who possesses it. However, the process creates X Eggs and X Characters. Continues on "Shugo Chara! Encore!"

Mashiro was always alone, whether at high school, cram school, and home. Until one day, Mashiro met a youngster with a strange atmosphere. Holding the thought of “I want to change”, she took a big first step forward--even though her legs are small--seeking the path of Eden.

Contains 4 fantasy stories (2 plausibly tying into the main story), 1 story taking place after Harima announces he's a mangaka, and 5 stories occurring after the final chapter (with 2 being a part of the possible future)

A collection of short stories. 1) Love Dancing Beneath My Eyelids College student Numakami has known for a long time that his classmate Mahara is in love with him. But Mahara is pure, innocent - and still a virgin. For some inexplicable reason, this makes Numakami feel annoyed at being the object of his affections. 2) She's Missing Yanagi is in love with Kobayashi, who can't seem to stop talking about Adachi - a girl in their class. What will become of these three teenagers and their complex relationship? 3) Minun Musiikki A quiet pianist and an obnoxious, outspoken cellist often find themselves alone in the music room together... 4) Yes It's Me The story revolves around Toma, who is head-over-heels in love... with himself! However, so is everyone else around him; and he knows that his business partner and old friend, Enoki, is no exception. Toma doesn't blame him. After all, he is only the most brilliant, beautiful, and all-around perfect person to ever walk the face of the Earth! Who wouldn't fall for him? Weirdly enough, Enoki is convinced that Toma returns his feelings. But they should both know by now that there's no one he loves more than himself... right? 5) Yes It's You 6) Loathe! 7) Dreams Unfold at Night 8) Yes That's It

From ShoujoMagic:

Ever since he was small, all the girls in the neighborhood have fawned over Tsutomu Yamaguchi, whose name came from a song and whose adorable face closely resembles the monkey character Monchichi's. Even back then, it was enough to make his friend and neighbor Mikako sick. Now that he's a little more grown, Tsutomu looks like the lead vocalist of Manbou, Ken Nakagawa (Midori friend/boyfriend from Tenshi Nanka Ja Nai; we meet main characters from Tenshi on market/fest), and that makes him even more popular with the ladies. But Mikako--now a trendy teen with modern sensibilities--couldn't care less. Or could she...? Gokinjo Monogatari is a sharp-witted and stylish slice-of-life story!

Continuation (after years) in Paradise Kiss.

Gorou has a crush on his older stepsister Haru. Unfortunately for Gorou, Haru happens to love teasing him sadistically in every way possible.
A 4-koma comedy about their wacky day to day life and interactions.

Hoozuki-san Chi no Aneki - Nano Shucchouban and 2 chapters of Hoozuki-san Chi no Aneki - Nano Branch are included in volume 3.

From etc:

Eiko is something of a plain Jane and a doormat, while her best friend Moe is a head-turning beauty. Despite their differences, their friendship is as strong as ever.
Guys are always asking Moe out, but her answer is invariably "Only if you promise to put Eiko before me."

Rintaro Senkawa is a middle aged guy who got a little drunk one night and died. But that is just the beginning of this story as Rintaro finds himself most unexpectedly in Hell where he meets his guide, the devil Koyori.
Can Rintaro take his situation seriously enough to repent for the sins of his former life, or will he face the favored weapon of Hell- the spiked iron club?

From Anime Waves:
The woman Tsutomu encounters in college was older and smaller than he is, and for some reason, looks like the same girl in his dreams. The heart-pounding love affair between him and the "older woman" begins.

The story explains the day-to-day of a college freshman Yūta, who is just starting a new life in the School of Literature Department of Tama University. While Yūta grew up with his sister, when she married a divorced man with two daughters, Yūta left her to live by himself to distance himself from that new family.

About 3 years later his sister asked him to visit and babysit her girls. His life was turned upside down when the girls' parents went missing. Yūta now has to live with his sister's three daughters: a tsundere (Sora, 14 years old), a little demon (Miu, 10 years old) and a baby girl (Hina, 3 years old), two of which are from a previous marriage and not related by blood, in a six tatami mat sized room.