Arata Natsume works at a child guidance center, is in his thirties and single with no plans for marriage. But one day, he receives a request from the child he was in charge of, Takuto, to "meet the criminal who killed his father". That serial killer is Shinagawa Shinju, also known as the "Shinagawa Pierrot".

The stage is the eve of the French Revolution. There is the commoner Gideon, who wants to save the impoverished country side-by-side with the members of the Estates General. Then there is the aristocrat, Georges, who will use any means to achieve his purpose. A man who wants to change the country, and a man who wants to destroy it. Both begin their journey forward. Will their joint efforts of love and hatred, justice and evil lead them to a hell of bloodshed, or an ideal future?

From Etc:
Dr. Katou is an ambitious woman who seeks to revolutionize the corrupt and inefficient Japanese medical system from within by becoming a professor in a teaching hospital. She enlists a maverick surgeon, Dr. Asada Ryuutarou, to help her with research that would catapult her to a professorship should they succeed and publish. However, Asada's refusal to conform to the system soon threatens to destroy not only her plans but her entire career. Katou is prepared to do anything, including going along with the system, in order to achieve her end goal, but she begins to question whether she has gone too far as Asada's actions bring many of the system's shortcomings to light.

Note: Won the 50th Shogakukan Manga Award for general manga in 2005.

From MangaHelpers:
In the 1950s, an old woman was brutally murdered on the face of a clock tower by her adopted daughter. Two years later, the clock tower is known as the 'ghost tower' and it is supposedly haunted. Through an unusual series of events, a young NEET man named Amano Taichi is attacked by someone or something in the same clock tower, and finds himself bound to the clock face to be killed in the same way as the old woman. Luckily for Amano, he doesn't meet the same fate. He's rescued by a mysterious person who claims his name is Tetsuo. He is searching for a treasure that is connected with the ghost tower, and he wants Taichi to be his partner. Taichi, whose life has mostly consisted of poverty, loneliness, and pornography, is enticed by the idea of gaining extreme wealth. He's further convinced when a house fire leaves him without a home and depends on Tetsuo's charity. The adventure is going to be very dangerous, since the same 'enemies' who attacked Taichi before seem certain to try something again! Not to mention, Taichi really knows very little about his new partner.