Katakura Tsumuri is the school nurse who runs the high school's infirmary... which is good, because she's the one who needs to make use of it the most. Tsumuri has a weak constitution, and constantly tires herself out or faints from doing her day-to-day job. It doesn't help that she's also a space cadet and lazy at heart, so when she's not asleep in the infirmary's bed, she's got it covered in snacks and games. Her younger brother, Kouta, is a student at the school and spends plenty of his free time assisting his sister and unwillingly rescuing her from the demands of adulthood.

Mukai Sachi is extremely unlucky. Stubbed toes, lost items, bird poop... it all happens to her. Her most unfortunate problem, though, is Gokurakuin Misako, the only member of the Occult Research Society. Misako is an honors student, beautiful, very strange, and friendless. She is interested in Sachi's "power" because she wants strange, unexplainable things to happen to herself, too. The problem is that Sachi has absolutely no interest in the occult, so Misako's continued, oddball attempts to get her to join the Occult Research Society are yet another piece of bad luck for Sachi!

Sotomura is a high-school girl who is feared as a delinquent and avoided by most students. From her light-brown hair down to her long skirt and harsh manner of speaking, she completely seems the part.

But after Sotomura rescues a girl named Haruno from some bullies, Haruno decides to try to get to know her better. Haruno is surprised to find out that Sotomura isn't a delinquent at all and is, in fact, just a very socially awkward girl that's bad with words but wants to make friends. She enjoys cooking, handicrafts, and hitting the supermarket sales. Sotomura also loves cute and fancy things, but she hides these girly traits because she feels they don't suit how she looks.

Haruno's first step in helping Sotomura is to try to teach her how to smile, because whenever she tries, it ends up as a scary grin. Thus begins the story of Sotomura's attempts to make new friends.