Sommelière tells the story of Kana, a poor orphan who works in a wine farm that is supported by a mysterious, charitable man whom she never met, known only as "Mr. John Smith". One day, a messenger suddenly arrives with a proposal from Mr. Smith: Either work in a restaurant in Tokyo, or the farm's funding will stop. Why is the charitable Mr.Smith suddenly threatening to stop supporting the farm? Will Kana accept the proposal? And what does fate have in store for her in Tokyo?

The story of the Sasakura Ryu and Eden Hall, a small cocktail bar in the Chiba area of Tokyo, where troubled customers come for the "glass of the gods," which with Ryu's assistance helps them to resolve their often highly emotional problems.

The above is the synopsis of the anime. In the manga, Ryu starts out working in a bar called Lapin.