In the tradition, it is only the strongest women that can rule this kingdom. The battle that decides the strongest woman done once every four years. This battle is called Queen's Blade. Erina is ordered to bring back her runaway sister, Reina, who's participating in the Queen's Blade tournament.

Only the strongest woman is worthy of being Queen. On this continent, a desperate struggle to crown the new Queen is held every four years. The Queen's Blade.

The series' protagonist Annelotte is seeking the head of reigning Queen Claudette for revenge and justice. Following her swift defeat and imprisonment Annelotte is now building a rebellion army to take on Claudette once more!

Nao, Yuki, Tomo and Rio are four brothers working as maids in their family's maid cafe Cherry Girls.