On the Island of Eden, people awaken to their unique ability called "Xeno." People who are able to use Xeno are called Xenotakers. At the Holy Cathedral High School, Yohane Bonaventura is the only person in their class unable to awaken a Xeno. Will he be discouraged and give up, or will he be able to fulfill his promise to his late mother?

Ten years ago an attack by giant monsters called Idola floating in the sky leveled Washington D.C. and awakened humanity to the existence of other life forms. It took years to develop a measure to counter them, via humanoid Idola-derived robots that are controlled by pilots via brain waves.

Ilya Kravitz is a young wheelchair-bound kid and prospective pilot taking the pilot examination who lives alone with his sister Anna Kravitz in New York City. Will he manage to fulfill his dream of becoming a Pilot? How will he fare against the Idola?

Two siblings making their way through a world rife with atrocities…