The brothers perform the banned alchemic technique of human transmutation in a effort to resurrect her when Trisha dies of the plague. As a result, the transmutation backfires and in law with equal exchange, the left leg and Alphonse's whole body of Edward are ruined. Edward loses his right arm to save Alphonse's soul, binding it having a blood seal into a suit of armour. Roy Mustang invites Edward to become a method to restore Alphonse's body to be researched by a State Alchemist. Edward triumphs, becoming the name according to his prosthetic post limbs, the Fullmetal Alchemist.
Three years on, the Elrics search for the legendary Philosopher's Stone to realize their aims. Marcoh sends his notes to be found by them, however they learn the essential factor to really make the Stone is human sacrifices. The buddy of Mustang, Maes Hughes, carries on their research, but is shot dead with a disguised Envy for finding the strategies of the Homunculi.
Seeing with Izumi, the Elrics learn human transmutation was perpetrated by her on her stillborn child. The rogue homunculus Greed captures Alphonse, but is saved by Amestris' president King Bradley, shown to function as homunculus Wrath. Greed is thus melted down by and reabsorbed inside the originator Father of the Homunculi. Winry and the Elrics return to Central City to go to with Hughes but learn of his passing. Lieutenant Maria Ross is framed for Hughes' homicide, but is apparently killed by Mustang. Yet, Edward learns Ross' departure was staged so she can be smuggled by Mustang from the united states to Xing, helped by Xingese prince Ling Yao. Hohenheim is reunited with by Edward but despises him for his long absence at residence.
As the narrative advances, the Homunculi are encountered by the protagonists repeatedly. Mustang kills lust; Mustang and Ling captures Gluttony, however he ends up consuming Envy into his null, and Edward, Ling -like belly. Gluttony takes Alphonse to meet Father, but Ling turns right into a homunculus, specifically the newest avatar of Greed, when the others escape from the belly of Gluttony. The Elrics are released to continue their pursuit provided that Father isn't opposed by them.
Locating an underground tunnel beneath Briggs, General Olivier Armstrong find Father and the Elrics has been creating a national transmutation group and intends to give its citizens so he is able to ascend to godhood. Greed recovers betrays Father and his previous self's memories, teaming up with after, and Edward, the chimera minions of Kimblee Hohenheim. Hohenheim discloses to his sons individually that he's not mortal, turned right into a living Philosopher's Stone by Father four hundred years back.
The Promise Day arrives and Father prepares to begin his strategy having an eclipse and the ones who attempted human transmutation as his sacrifices that are essential. The various protagonists conflict with Father's minions, with all the Homunculi expiring. Following a forced Mustang, as well as the Elrics, Izumi, Hohenheim are collected as the causes dad activates the national transmutation. Nevertheless, Scar and Hohenheim activate the Amestrians to be saved by countermeasures. Greed is ruined by Father, although dad is faced above ground where the protagonists fight him to wear down his Philosopher's Stone.
Alphonse, whose armour is all but ruined through the last conflict against Father, gives his spirit to regain the right arm, who in turn ruins Father's Stone, sending him back to the ethereal Gate of Truth of Edward. Edward loses his power to do alchemy to recover soul and Alphonse's body. Hohenheim sees the grave where he dies having a grin of Trisha.