From Noctis Op.92:
What exactly is the difference between a robot and a human?

In a dystopian future in which robots are becoming increasingly commonplace, a young boy named Hogu lives in near poverty with his grandmother and sister. Though he innately possesses a kind soul, he is ostracized by his classmates and frequently bullied. At the beginning of the story, we find Hogu, friendless and alone - until he meets a robot girl...and our story begins.

Humanity, having faced extinction at the end of the 20th century, would not have entered the new millennium if it weren't for them. In 1969, during their youth, they created a symbol. In 1997, as the coming disaster slowly starts to unfold, that symbol returns. This is the story of a group of boys who try to save the world.

Won the Kodansha Manga Award in the category "Best General Manga" in 2001.
Won the Seiun Award for Best Comic in 2008.

From Anime News Network:

A collection of short stories that look to mankind's exploration of space, and examine the possibilities that we could face when we decide to take those first fateful steps into the unknown.

A Violinist That has talent and seemingly more connections than he lets on is used to babysit a powerful SS rank illusionist girl she seems to have known him since she was young but he most likely don't remember her. ~ Yeavon

Abara is set in a dystopian world, filled with large structures. The story revolves around creatures known as Gaunas, those who can shape bone like armor and weaponry around themselves by transforming. The transformation begins around the spine and then shapes layered armor.

The story focuses on one such Gauna known as Kudou Denji, though he uses Itou Denji as a fake name early on.

Abara means "ribs" in Japanese.

Volume 2 contains Digimortal
A mercenary in cyber-armor battles a repressive cyborg regime.

Description from Viz: The story A, A' raises a troubling question: How would you feel if your lover died - and was replaced by a clone? Could you recreate your relationship with someone who was physically exactly the same but didn't share any memories of your life together? In 4/4, teenaged Mori flunks out of an ESP training program. But when he meets Trill, a beautiful Unicorn, his latent abilities begin to blossom... In X+Y, Hagio uses science fiction to explore questions of gender and sexual identity. Time has passed, and once again, Mori finds himself inexorably attracted to a member of the unicorn race - but this unicorn is male... and so is Mori. X+Y won Seiun Award in manga category in 1985

From Manga-Sketchbook:

After a major natural disaster, earth is slowly transforming into a desert in which mankind tries to survive. Water becomes a precious resource and the center of political intrigues. In the middle of this, a young boy, member of a gang, encounters a beautiful girl who's a merciless warrior and holder of the key to the salvage of humanity.

A small coincidence makes history!
The story of the earthlings and superhero Aimer's efforts to block an alien pumpkin gang invading earth is about to unfold!

Taken from Solaris-SVU:
Ikuru is a boy who doesn't have long to live. Growing up questioning the purpose of his life and the reason for his impending death, he's constantly confused and lonely. After learning that he doesn't have much time left, he requests that a special "girl" called a AGH-RMS (Artificial Genes Human Regenerated for Mental Support) be given to him. These people are genetically made so that they help heal and ease the mental burdens of the terminally ill. This manga is cute, sad, and ultimately a story about life, death, and humanity.

On one side, we have a guy living a boring and meaningless life meets Touko, a pretty girl, and it turns his life around. They get married, but three months later she tells him she is an alien from a far away planet, and that she must return to her home planet in a few days. Is she making excuses? Is she really an alien? Will he let their marriage end so easily?
On the other side we have Honda Haruno, a girl which has absolutely no other recollection other than being "sent" by her superiors to gather information about humanity; as a secret agent she needs to do her best as to learn as much as she can about society without giving away her true nature.... However on her first day of school she meets this boy "Isuzu", who has extensive information about UFOs, invaders from other space & related topics... Haruna not only is surprised to see that her cover has been blown out right from the start, but also she must know how this Isuzu fellow knew about her. Even though they don't realize it; Haruna and Touko are actually neighbors in the Akatoki Hoshi Residence... but, Is this all?

Komatsuzaki Ran is not a normal girl. Raised by wolves, psychic powers, the ability to turn into Akai Kiba (The Red Fang)...and a lot of people after her.

James Block is a former sports star whose criminal endeavors landed him in jail. In prison he meets "Dr. F", a strange old man who tells James about a beam that can turn living things invisible.

After escaping from prison, James finds and uses the laser on himself. But, because the beam has not been perfected yet, it only rendered his skin invisible, leaving his insides visible to the outside. Angered at his disfigurement, James takes the name "Alabaster" and begins eliminating the hypocrites and the boastful. He is joined by Ami Ozawa, the granddaughter of "Doctor F", who was rendered invisible after the doctor used his pregnant daughter as an "F Beam" test subject.

On their trail is Rock, a vicious FBI agent.

Akira is set in the post-apocalypse Neo-Tokyo of 2030, a vast metropolis built on the ashes of a Tokyo annihilated by an apocalyptic blast of unknown power that triggered World War III. The lives of two streetwise teenage friends, Tetsuo and Kaneda, change forever when dormant paranormal abilities begin to waken in Tetsuo, who becomes a target for a shadowy government operation, a group who will stop at nothing to prevent another catastrophe like that which leveled Tokyo. And at the core of their motivation is a raw, all-consuming fear. A fear of someone or something, of unthinkably monstrous power known only as "Akira".

Note: Won the 1984 Kodansha Manga Award for best general manga, won the Harvey Award for Best American Edition of Foreign Material in 1993 and was nominated for the Harvey for Best Graphic Album of Previously Published Work in 2002.

Collection of short stories including:

• Akatsuki no Fumi
The year is 2435, and Takatsuki Minori has developed a machine that can transport historical figures from their original time to the present. His son, Akira, one day discovers that the machine has gone haywire for no reason and ends up accidentally summoning the 16th century samurai, Mori Ranmaru...

From Del Rey: A strange virus is making its way around the globe, causing its victims to commit suicide. In less than a week, it's become a lethal pandemic. But for a unique few, it does just the opposite... They evolve and become "Power Users." Taisuke Kanou and his best friend Hirose both become power users, but Hirose sides with Katsumata, a strange man with no regard for human life. The story follows Kanou as he discovers the secret behind his powers, encounters reporters, other power users, and even the military, as he tries to get his friends back.

From CPM: The girls have finally graduated 6th grade and are now in Junior High… but are they really prepared for the challenges that await them? There's a new girl in town and she seems to be hosting an entirely different kind of alien… is she a new ally, or will she be the Earth's latest threat?

Set within a ravaged world, a girl protects the people from these monsters is interwoven into this mysterious fantasy.

This is a oneshot from the Moonsorrow Collection II.

"Originial" doujinshi by the circle Moonsorrow.

From ADV:

A mysterious creature has fallen from the sky and landed right at young Yuina's feet! Branded as the master of this new angelic being, Yuina is forced into an otherworldly pact, one that will take her beyond the clouds and into battle against a new and yet hauntingly familiar evil, one that patiently waits in the shadows.

When a devastating meteor struck Earth, Earth's guardian angel Lyu was so tortured by guilt that she killed herself. Mo Ye, the demon who was in love with Lyu, is determined to find her again. Has he found Lyu's reincarnation in the human Xiao Tian Nu?

27 year-old Ayukawa Yuuji has never been much of a man. He's more comfortable sewing than fighting, he faints at the sight of blood, and his fiancee is tougher than he is. He's also a terrible pushover. So when his boss at the medical lab volunteers him for some experimental drug therapy, how can he possibly refuse? All's mediocre for Yuuji: master of the pathetic.

Mediocre, that is, until a juvenile mass murder suspect jumps out from under Yuuji's bed, declaring him his "mate." Before Yuuji has time to argue, the stranger transforms into a 16 foot-tall dinosaur and beheads his roommate...

Yuuji suddenly finds himself the sole target of a lost race that turns into dinosaurs, an extremely scary woman with a Goddess-Complex, the yakuza, a mad scientist and one 17 year-old boy who really, really, really wants to sleep with him.

Series:
1. Aragami no Ichizoku (4 volumes)
2. Daichi no Okite (2 volumes)
3. Genshi Sairai (10 volumes)