In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his brother and himself... the legendary Philosopher's Stone

Note: Won the 49th Shogakukan Manga Award for the shounen category in 2004, the UK's Eagle Award for favorite manga in 2010 and 2011 and the Seiun Award for best science fiction comic in 2011.

Luo residence's illegitimate child, Luo Linjing, received the nymph project cultivator of the future accidentally. She had always been weak and sick due to premature birth. With the help of the system's "little god," she gradually became a strong beast master and doctor. However, she never expected that a conspiracy which could shake both the human and beast world would slowly unfold before her very eyes...

<Cheating Men Must Die> Side Story. The beginning of intern Su Lüxia journey of abusing scum.

Starting today, I retire. But what should I do...... I don't have any talents, and I don't have the brains for business. My only talent is to defeat enemies all over the world. What a pain......

Lotus is a book clerk who works hard to succeed the bookstore in his parents' home. One day, when I got a mysterious book at work, I was taken to another world! The way to return is to live deeply with people in this world. To that end, Lotus who is about to start work has come to talk about whether to open a bookstore. Lotus decides to start a bookstore from scratch, but ...!? A bookstore clerk who loves books, a different world work fantasy, a long-awaited comicalization!

Qin Yu was killed a few hundred years into the future during the apocalypse due to a misjudgment. He then traveled back in time before the apocalypse kick off, relying on his battle hardened apocalypse experience and techniques, Qin Yu rapidly developed into a formidable opponent, passing through hurdles, saving the world all while protecting his beloved sister.

Yoh Asakura is a shaman--one of the gifted few who, thanks to training or natural talent, can channel spirits that most people can't even see. With the help of his fiancée, Anna, Yoh is in training for the ultimate shaman sports event: the "Shaman Fight in Tokyo," the once-every-500-years tournament to see who can shape humanity's future and become the Shaman King. But unfortunately for Yoh, every shaman in the world is competing for the same prize…

From Storm in Heaven:

Kasane is your average kendo-obsessed girl, when a brush with a mysterious sword sends her back in time to the Sengoku Era. Stuck in an unfamiliar time and place, Kasane also has the poor luck of winding up right in the middle of the turmoil that surrounded Oda Nobunaga's rise to power!

After having been sealed for 300 years, the demon lord Giri reawakens and sends off his monster minions to wreak havoc in the world. King Uruga XIII decides thus to place announcements everywhere in the kingdom in search of a legendary hero who can defeat Giri. In the king's castle will be held a competition to discover who the true hero is. Forced by his hero-wannabe parents to go to the castle, Nike first visits the witch's house, where the magic-learning Kukuri joins him. Together they travel around the world defeating monsters, gaining new abilities and trying to uncover the mysteries surrounding the Migu Migu tribe.

Based on the Shin Megami Tensei If videogame.
The setting is Karukozaka High School, which is mysteriously sucked into a void and emerges in the realm of Makai, a world of demons. Most of its students and school employees are trapped in the other world along with it.

From Kirei Cake:

Iride Akatsuki is a popular game footage uploader. He wakes up one day to find that he's been kidnapped and taken to a strange place, along with a number of other uploaders who specialize in different genres of games.

A mysterious alpaca-headed host gathers them after the initial stage, to explain how the game will proceed. Will the group of gamers clear the game and make it back to their real lives?

In order to find their teacher who had suddenly disappeared, Yotsuki and Kotowari went on a journey, visiting six of her friends as she instructed them to.

Blessed with the gift of magic, with the search as their goal, the girls' incident-filled fantasy story begins.

Yuzuki is a call girl - a sex worker who doesn’t make prostitution her main profession. She gets sent to another world, and in order to get back to her own world she has to collect orgasms from all the different fantasy races that exist in the world she was sent to.

So yeah. It’s similar to JK Haru is a Sex Worker in Another World, but compared to that the fanservice is more explicit and the story itself less dark.

Alternative raw: https://seiga.nicovideo.jp/comic/40827

Fang Haotian is a young boy who is deeply in love with a girl called Ningyu, but her parents are opposed to their relationship. Ningyu is arranged for marriage to another man. Can he become strong enough to take back his beloved Ningyu from this man?

Lupin the Third and his motley crew return in Shin Lupin III! This time, several of the stories are either brand-new or adapted from or to the Lupin Part 2 anime, and the beginning story was even animated by itself several years later! Lupin the Third is the grandson of the famous literary thief Arsène Lupin, and his partners in crime include the sharpshooter Jigen Daisuke, the stoic samurai Goemon Ishikawa the Thirteenth, and the on-again-off-again lover/rival Fujiko Mine. Their object is to steal the most valuable and important items while evading the guard of Inspector Koichi Zenigata, the ever-vigilant ICPO chief whose life goal is to capture Lupin, but when it’s fulfilled, he’s lost his purpose! What kids of exciting adventures will they get themselves into in...Shin Lupin III!

A seinen take on Saito's classic Survival. It tells about the drama of those who survived the fall of a meteorite on the Pacific Ocean after a failed attempt of destroying it with a missile. Cities are destroyed by big earthquakes, food runs short, illness spread quickly. In the midst of this scenario, Ootomo, the main character of this series, will do whatever in order to survive.

From Aerandria Scans:

The beautiful singer Lucille and his orchestra invite you to the city of fear where puppets hunt down humans. The puppets are playing an oratorio of magic and illusions!

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This manga also features the unrelated short story Camelot Garden in vol. 5.

In the Sengoku Period (1579), there is a young woman who has lost everything, and dedicated herself to seeking strength and a death on the battlefield. Reiri once lived happily with her family, until the day soldiers came by after a battle. Her father, mother and brother sacrificed themselves in order for her to survive. She was only saved with the intervention of Okabe Tanpa no Kami, who had been sheltering in the village. In his service, she grew and learned to fight well, chasing her goal of a death in battle. However, her path to death may not be as short and straight as she hopes.

Its been 15 years after the last Great War. While the scars of wars appear to have vanished on the outside.In truth, the world has become a much harsher place.Follow the journey of Felix and Bay on their quest to find someone from their past.

Continuation of Kono Subarashii Sekai ni Bakuen wo! Adapted from the light novel series of the same name.