Tastumi is a normal boy going to school and living with his strict older brother. Orphaned at a young age, his brother has been both a mother and a father to him. One day, he and his friends are about to rescue a beautiful girl from being harrassed when she beats them up herself. When she sees Tatsumi, she suddenly calls him "Rui". What does this mean? Who is the girl? Why are there strange men attacking him all of a sudden? And why is his brother suddenly so different??

An order has been sent out to hunt down the existence of an Asklepios, a Greek demon god of medicine, whom the Church believes is practising unorthodox methods. A member of armed force group assigned to this mission by the name of Luca encounters two kids who saved him from an injury he faced during a brawl. Who are these kids and can they help out Luca with his personal reason for doing this assignment? One-shot turned series in September 2008.

From http://www.niko-niko.net/sites.html: Ashita no Nadja is the story of a young girl who grew up in an orphanage in England. One day she learns she may not be an orphan after all, and suddenly finds herself chased by some strange men. She ends up fleeing the orphanage and joins a travelling troupe of entertainers. The show follows her travels across Europe as she tries to find her mother and figure out who she really is. A bit more info about the manga is at http://www.niko-niko.net/nadja/ under 'Extras', and info about the anime series and merchandise.

Frederica, the older sister. She contracts a demon, hunts the souls of the wicked, and sends them to hell. She is the silver seal. Howly, the younger brother. He was given his life by a demon, according to his sister's wish. He serves and protects the silver seal. He is the warrior seal. What will the world give to them?

Battling incredible odds and critical public opinion, a trio of astronauts fight to disengage a runaway generator in impossible conditions and silence longtime critics at the same time

From Storm in Heaven and one of their legacy groups, Bamboo Feathers:

Fraw and Kio are angels, and it's their duty to protect the passage of souls to Heaven. When the two were growing up, Kio always looked after Fraw. However, their roles are suddenly reversed when Fraw is promoted to one of the highest ranking classes of angel, and Fraw takes it upon himself to protect Kio.

Can Fraw keep his new position a secret while he and Kio battle against the Manifis, evil spirits that feed on humanity? And what is so unusual about Kio and his wings...?

Originally a oneshot called "Eden."

When Lord Dahn-Guh "accidentally" unleashes powerful demons unto the land, he orders the fool Ondal to recapture them! Unable to fulfill the task on his own, Ondal is accompanied by Hae-Moh-Soo--a legendary, foul-mouthed warrior who helped to trap the demons in the first place--and...David Copperfield?! Along the way, they come across quite the interesting array of characters: a gang of armed nuns, the mysterious Samson with singing powers, the twins Pai and Pei, and so many more!

From Tokyopop:
An ancient seal has been broken, sending a flood of demons into the mortal realm. Hizuru Oborozuki and Takuya Hijou, descendants of the great savior who banished the demons in the past, must fight the evil spirits using their mystical powers. In order to give the world a fighting chance, Takuya uses his music to transform Hizuru into a beautiful warrior. Some things are worth fighting for, but is the Earth one of them?

From Tokyopop: After the abduction of his brother Kotaro by the Machine Empire, Teppei Takamiya joins forces with X, one of several highly-advanced, artificially intelligent machines known as B'ts (pronounced 'beat'), to rescue him.

From here:
Sunao always thought she'd fall in love when she started junior high school. But there aren't any attractive boys at school. Still Sunao doesn't give up and meets two handsome upperclassmen. The kind and sensitive Toru and the cheerful and friendly Kaoru are members of the school Magic Club, which Sunao also joins. Then she finds out that Toru and Kaoru are actually thieves known as "B-apostrophe" who need Sunao's help as a master of the martial art Shinbu-ryu. They are trying to find the treasures hidden by the illustrious thief from the Taisho Era.

According to the legend, whoever finds seven glass balls and solves the seven secrets, hidden in each, will win treasures worth 30 billion yen and learn a strange magic secret. Sunao is surprised by this and becomes part of the team because she is attracted to the boys. It's like being in heaven surrounded by two such beauties.
But they are not the only ones after the treasures. Somebody called "B" always gets in their way. "B-apostrophe" might know who "B" is... Sunao is swayed by her complex feelings: She likes Toru, but occasionally feels a pull towards Kaoru and even to "B" when he makes contact with her!

Leto is employed as an apprentice by the skilled mercenary Alpha, from the mercenary unit Boreas. He struggles to rid himself of his apprentice status and be accepted by Alpha. However, as a mercenary, many painful encounters and terrible experiences await him…

A series of fairytale-like stories, loosely connected by the ongoing adventures of the enigmatic Hwa Ryungang, a man with strange powers and a connection to the spirit world, and Moohwe, an irrepressible wanderer with a mysterious past.

After being bullied at his old school, Makoto wants to be the main character of his own story. When he finds a bill with his face on it on a school trip to Kyoto, he takes it as a sign, which leads him to fall into a river. Once he comes to, he realizes that he has been transported back to the period of time in Japan known as the Bakumatsu!

Kazuki's had a 16 year grace-period of peace and relative normalcy; smuggled to Japan and raised by a kindly old woman he's grown up to be a bright and friendly boy. His childhood friendship to the girl next door is just beginning to blossom into romance and the death of his ward leaves him with enough character-building angst to set him up for just about any cliche shoujo adventure Yukari Ito has in mind. Unfortunately, Yukari Ito is TOTALLY insane and has decided to make him a vampiric kitten engaged from birth to a Nightmare. (from doki-doki)

"Basara - The spirit of freedom which denies old authority, transcending traditions and customs."

Born under a prophecy that will liberate and unite Japan, Sarasa has had to take her brother Tatara's place as the "Boy of Destiny." Fighting for the oppressed, Sarasa journeys across Japan to gain allies and defeat her enemies--all while keeping her identity a secret!

Basara won the Shogakukan Manga Award for shoujo in 1992.

Futaba, a boy that has grown up in an overprotected family, suddenly finds himself on the other side of the world, where he meets Kiara, the Amaranthine. They journey to find Kiara's true master, and along the way they meet a curious cast of characters, including the wizard Belbel and the prince Virid.

Pronounced - Bee heun From: Easy Going Scans There are some heroes whose names you do not know, whose faces you have not seen... They operate secretly, and their actions can make a difference in the outcomes of wars. Be Huen is the story of such a man. To follow his story, one must search in the shadows, for that is the only place you could find him... Webtoon from Naver Please address this work as a Manhwa (Korean word for cartoons)

Tsutomu Nihei returns with another addictive manga (see BLAME!), set in the not-so-distant future (3005 A.D.). It follows a character by the name of Kanoe Zouichi and the mysterious Kanoe Fuyu whose luminous form is integrated into the system of his bike. They are agents sent by a powerful organization to retrieve the human with the ability to resist and transmute the NS5 infection that is spreading across the world, named Yion/Ion Green. However, their mission is delayed by the reckless actions of the Public Health Department's taskforce and the kidnapping of Yion/Ion Green. Will they complete their mission? Where has Yion/Ion Green been taken? These questions will only be answered as more volumes are released. The art in BioMega is similar to BLAME!, with its complicated concrete sprawl and ludicrously wide, empty spaces. However, things seem to happen at a more reasonable pace. In this manga, there is emphasis on the swiftness of the attacks made by Zouichi, such as the gun being sheathed just before the enemies fall to the ground. Speed is crucial in this manga, unlike in BLAME!, and the plot develops just as quickly. An interesting read, especially if one has enjoyed BLAME!

Man is having a hard time finding food and getting rid of their trash, so science comes up with a bio-engineered animal that survives by eating trash, and is then killed to feed humanity. But the self-replicating, endlessly hungry killing machine gets loose in Tokyo...