Fushimatsu Fushio is an unpopular loser who is screwed over by a lazy Cupid, Kyupiko, who gives him the curse of being hated by the entirety of womankind. Years later God realizes how horrible a situation this is for the poor boy and kicks the lazy Kyupiko out of heaven until she fixes the situation.

Seton Academy, a school full of animals where, thanks to population decline, there are fewer humans than any other creature. Mazama Jin, an animal hater and the only human male in his class, falls in love with Hino Hitomi, the only female human, the moment he lays eyes her. However he soon finds himself entangled with various other creatures after he reluctantly joins the 'pack' of Lanka the wolf, the only other member of her pack.