MF Ghost takes place in the 2020s, when self-driving cars are ubiquitous in Japan. Centered around Kanata Livington, a Japanese driver who goes back to Japan after graduating at the top of his class at a racing school in England. MF Ghost also focuses on the MFG, a racing circuit on public roads that has garnered attention worldwide.

Only the fearless survive in the white-hot world of street racing, as teams take on dangerous roads in the shadow of Mt. Akina. Behind the wheel of the mysterious "Ghost of Akina" is Takumi, on his way to becoming the greatest racer ever.