In 1912, a young woman tracks down the elderly Nagakura Shinpachi, determined to hear the true story of the Demon of the Shinsengumi, the Vice Commander Hijikata Toshizou. Hijikata's story begins in 1859, when he is a violent young man honing his sword skills while peddling his family's medicine. Soon, in his quest to find stronger people to fight, Hijikata starts to come into contact with others who will eventually be his comrades in the Shinsengumi. The first one to make an impression on the brash young man is Kondo Isami, who proves to be a better fighter than Hijikata...

Like gods, doctors hold the lives of their patients in the palms of their hand. When doctors go bad who will stand up to them when the law is powerless? E.D.D is the fabled agency that works to rid society of these crooked men. When Dr. Kasahara meets his untimely termination from his hospital he is recruited to the ranks of this mysterious agency. Join Kasahara and Kojima as they Eliminate Dangerous Doctors.