Is this a comic or a game? When the players aren't around, the NPCs start to worry. Join a band of silly NPCs (non-playable characters) as they attempt to free their cursed village and find their creator!

Hagiyoshi Tamaki, a member of the school's occult club, decides to summon the 'Jet Black Witch' to bring despair to the ignorant masses of the world. Her fellow members in the occult club think she's suffering from Chuunibyou (middle-school syndrome), but agree to help with the summoning.

In the middle of the ritual, a mysterious girl dressed in black appears...

I have never seen such a cool girl!!
Daria (♂) is scrawny and has an appearance complex. One day he passes by Rubi-san (♀) who looks cool and is muscular!
“Muscle Girl” x “Tsundere Boy”. The muscular love comedy begins!

From Viz: There is a world of myth and magic that intersects ours, and only a special few can see it. Misao Harada is one such person, and she wants nothing to do with magical realms. She just wants to have a normal high school life and maybe get a boyfriend. But she is the bride of demon prophecy, and her blood grants incredible powers, her flesh immortality. Now the demon realm is fighting over the right to her hand...or her life! Black Bird received the 2009 Shogakukan Manga Award for shoujo manga.

An ordinary run-of-the-mill guy named Takase starts working in the Sales Department of a certain Real Estate agency, and his senpai at this job, Komai, looks more like a middle school girl than an actual adult due to her height and incredible cuteness! As they grow closer together, how will they deal with this unusual situation?

From Shinmakoku Scanlations :

One day, high school student Nagakura (normal dude) receives a love letter. Heading to the promised tree, the one who was waiting for him is Nishioka (super otaku) ...dressed in a sailor girl uniform!! Super eccentric "campus love" comedy in 4-panel comics~

An assassin decided to bring home a slave girl from a mission to raise her to be an assassin.

From Aerandria Scans:

Momozono Nanami's dad, a man with a penchant for gambling, disappeared after accumulating a huge amount of debt. Thus, she was chased out of her house by the debt collectors. When she met a timid guy being chased by a dog, he told her that he'd give her his house. She believed his persuasive talk, but when she went to his house… it turned out to be a shrine. Moreover, a guy with fox ears appeared, which made Nanami even more confused. What will become of homeless and confused Nanami?

Yariba Eiji (29 years old with intimidating eyes), a corporate slave whose only hobbies are video games and manga, gets through life by spending his time off relaxing at net cafes. One day, he happens upon Minamisato Karen (a 15 year old high school girl) and ends up scolding her. This leads to her warming up to the 29 year old Eiji...! Not only that, Eiji's little sister (a lazy middle schooler), childhood friend (a nosy ex-girlfriend), and his subordinate (a cool and serious girl) are also becoming interested in him. Love is coming at him from every direction! Juggling between his work and his newly developed ventures into romance, will Eiji's peaceful days ever return? From the creator of Oreshura, the forbidden age gap love comedy finally gets a manga adaptation!

In a world where only men can use magic, Eco is able to use magic for some reason despite being a woman. Even though I lived hiding that, unexpected things make magical things look like ballet. A cousin proposed “Do you want to work as a magician in the Ministry of Magic instead?” I can not even continue to live in this place, Eco decides to become a mage by falsifying her gender. However, if you go to the Magic Ministry, you’ll be in trouble with strange colleagues and funny incidents – !? The ill-fated work fantasy of the mage, will start its long-awaited commercialization!

During my part-time job, I met… my fated person!!

This is a TSF manga that stirs up just what you like.

Year 526 of the Liturgical Calendar. The world knew that witches existed, and that they practiced the notorious art of sorcery. Nevertheless, the world did not know anything about the study of magic.
The story follows a half-man, half-beast mercenary; humans mockingly call his kind the "fallen beasts". He always dreamt of becoming a human, but one day, he met a witch who would change his life forever. "Do you desire a human form? Then be my escort, mercenary!"
The witch introduced herself as "Zero", and explained that she was searching for a one-of-a-kind magical tome that bandits had stolen from her lair. Entitled "The Book of Zero", the grimoire supposedly contained valuable magical knowledge that could be used to effortlessly bring the world to its knees. Thus, in order to realize his dream of becoming a human, the mercenary must accompany Zero on her journey despite her being one of the witches he so loathed.

The "slapstick drama" begins with Seiya Kanie, a high-school boy who is invited on a date in an amusement park by a mysterious beautiful transfer student named Isuzu Sento. He is introduced to Latifa, a "real" princess and the park's manager, and is asked to be the acting manager of this "disappointing amusement park in the Tokyo suburbs."

Diet... to avoid the Bad End!
In a former life, Cosette was just a normal housewife. Now she's been reborn into the world of an otome game, not as the heroine, or even the villainess, but as a chubby unnamed NPC?! Is she destined to be pushed aside as the heroine follows her route, or can Cosette avoid the dark future that awaits her?
With six years left before the game's story begins, her first step is to improve her image. She'll use all the high heels, training equipment, and knowledge from her former life that she can to get herself into shape!
As she works to carve her own path, she gets wrapped up in royal intrigue, and winds up getting to know the prince?!
How will things turn out in this unconventional love comedy?!

Renellette is the beautiful daughter of a Count, with a position, an education, and enough property befitting her status, yet somehow she can't get married. One day, while searching for a marriage partner, she meets a man who rekindles memories of her past lives, a stalker who interferes with her marriage every time Renellete reincarnates! She struggles to shake off the obstacles between her and a happy marriage in this life, but his shadow is always flickering behind her... The long-awaited comedic love battle fantasy!

From MangaHelpers:

Supernatural creatures live alongside humans, but these "rares" are being hunted to extinction over time. An organization is being formed to protect these rares, and allow them to live their lives as they like. The starting members of this organization are few; there's the masked Fukumen, the Black Vampyr king AxL, and they are soon joined by the sweet-voiced mermaid Mirror. Together, they will protect the rares from the deadly hunters! [tethysdust]

When he was a child, Murakami was infatuated with a girl he called Kuroneko. She insisted on knowing about aliens and having met them, but no one believed her, even young Murakami was skeptical. One day, she decides to show him the aliens, but an accident occurs and Kuroneko dies while Murakami is left seriously wounded in the hospital.
Years go by and Murakami obsesses on finding proof of the existence of aliens because of a promise he had made with Kuroneko. Then, one day, a new transfer student comes to his class, who not only looks a lot like Kuroneko but is named Kuroha Neko.
And even though she insists on never having met Murakami before, the girl has superhuman strength and seems to even be able to predict the future!
How will Murakami's life change now that he has been saved by this mysterious girl that claims to be a magician?

Brand new Marvel Comics manga collaboration with artist/author Yusuke Osawa

Yamada Madoka (♂) loves all sorts of cute things! He grew up playing with dolls, sleeping with stuffed animals, and wearing girl's clothes that his sister made for him! The problem is, other people just don't understand, so when Madoka's family moves to a new city, he commits to acting like a boy at school. But what happens when his neighbor, Tanonaka Itsuki, finds out about his inclinations?!