The human army lost the battle with the vampires on Higanjima. Unable to prevent Miyabi's plan, Japan has become a vampire country. Six months later, there was a one-armed man fighting the vampires in abandoned Japan! The man's name is Akira Miyamoto. A warrior who had already tasted hell on Higanjima.

This is a continuation of the story of Higanjima, featuring an isolated island surrounded by fish demons and a population of warring vampires and humans. Ryousuke, his girlfriend Kazumi, and his friend Yamaoka are shipwrecked by the fish demons and wash up on the shore of this cursed island. They soon encounter the inhuman cruelty of the vampires first hand, before Ryousuke is able to meet up with the human resistance. Ryousuke wants nothing more than to escape the island, but mainland Japan may not be safe for long. If the humans don't defeat the vampires soon, then the vampires will succeed in their plans to spread the virus to the mainland!

Akira's brother, Atsushi, has been missing for two years. And recently a mysterious woman appeared and told him that she can take him to the island of Higanjima where she says she saw Atsushi. But she also asked that he bring a few friends along with him.